The Harris Orthopaedics Laboratory has spent over 50 years addressing adult reconstructive surgery concerns by innovating new surgical techniques, devices, and joint implant designs/materials. It has developed for large-scale use several formulations of highly-crosslinked ultra-high molecular weight polyethylene (UHMWPE) stabilized by remelting or vitamin E, and has changed the landscape of total joint replacement (TJR) by reducing the instances of osteolysis associated with TJR. These materials are now the gold standard in TJR, especially for the hip.The focus of HOL is on advancing TJR material development. Directed by Orhun Muratoglu, PhD, the preclinical materials research team develops novel UHMWPEs for improving implant longevity and expanding the safe use of TJR to younger and more active patients. Another innovation area is the development of non-degradable, hydrogel-based materials for repair of early-stage cartilage defects.The materials research team provides expertise in:• Material and polymer science• Polymer chemistry• Biomaterials• Biomechanics testing• Bench-to-clinic implant development• Testing of explanted devices to analyze in vivo effectsCurrent HOL projects have expanded to include other investigational areas, such as hydrogel-based treatment for degenerative spine conditions, and improving the mechanical and integrative properties of bone grafts.Another focus area is the follow-up and analysis of clinical implant performance to provide evidence-based feedback to patients and clinicians. Directed by Henrik Malchau, MD, PhD, the clinical research team develops local and regional implant registries in collaboration with orthopaedic surgeons (arthroplasty, spine, hand, sports medicine, trauma). It also conducts domestic and global prospective clinical studies on alternative bearing materials and new implant designs. These studies provide feedback on new implant performance and surgical techniques/skills to improve clinical outcomes.