The ever-increasing rapidity of technological change and global development creates demand for minerals and other extracted products. As these demands grow, so does the scarcity of raw materials, requiring miners to work in increasingly challenging environments to meet the needs of society. The School of Mining and Mineral Resources' Mining Safety Center of Excellence (SCE) at the University of Arizona is the pre-eminent research, education, and workforce training community that innovates mining methods toward achieving zero injuries, illnesses, and fatalities. The SCE addresses the most pressing mining safety, health, and risk challenges of the 4th Industrial Revolution, including:* Safety-focused supervisor leadership* Mine rescue and emergency self-escape* Optimized miner fitness-for-duty* Miner health and disease management Predictive analyticsSCE is working with our stakeholders to achieve zero harm to miners by:1) creating pragmatic and sustainable safety, health, and risk improvements in partnership mining companies;2) identifying, adapting, and promoting best practices across industry sectors, and3) improving access to tools, technology, and training so that the smallest mining operators can benefit.